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NERVOUS SYSTEM › PSYCHOLEPTICS › ANXIOLYTICS › Benzodiazepine derivatives
clobazam
N05BA09
Forms & Strengths
- Tablets: 5mg, 10mg
- Oral suspension: 5mg/5mL
Adult Dosing
- Initial dose: 5-10mg/day, divided into 2 doses
- Maintenance dose: 10-20mg/day, divided into 2 doses
- Maximum dose: 30mg/day
Pediatric Dosing
- Children < 6 years: not recommended
- Children ≥ 6 years: initial dose 0.25-0.5mg/kg/day, divided into 2 doses
- Maximum dose: 1mg/kg/day
Indications
- Adjunctive therapy for seizures
- Epilepsy, particularly Lennox-Gastaut syndrome and complex partial seizures
- Anxiety disorders
Mechanism of Action
- Potentiation of GABAergic activity
- Increase in GABA level and GABA receptor function
- Anticonvulsant and anxiolytic effects
Contraindications
- Acute narrow-angle glaucoma
- Hypersensitivity to clobazam or other benzodiazepines
- Severe liver dysfunction
Adverse Reactions
- Drowsiness, ataxia, dysarthria, and dizziness
- Behavioral changes, especially in children
- Anterograde amnesia, dependence, and withdrawal
- Increased risk of falls and fractures
Drug Interactions
- Potentiated sedation with other central nervous system depressants
- Increased risk of respiratory depression with opioids
- Enhanced effect of anticonvulsants and benzodiazepines
- Inhibited metabolism by inhibitors of CYP3A4 and CYP2C19
Curated Content: Needs Vetting Before Put to Clinical Use