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NERVOUS SYSTEM › PSYCHOLEPTICS › ANXIOLYTICS › Benzodiazepine derivatives
prazepam
N05BA11
Forms & Strengths
- Capsules: 10mg, 20mg
- Tablets: 10mg, 20mg
Adult Dosing
- Anxiety: 10-30mg orally 2-3 times a day
- Seizures: 10-20mg orally 2-3 times a day
Pediatric Dosing
- Not recommended for children under 12 years
- 12-18 years: 5-10mg orally 2-3 times a day, adjust as needed
Indications
- Anxiety disorders
- Seizure disorders (adjunctive therapy)
- Restless sleep due to anxiety
Mechanism of Action
- Enhances effect of GABA (inhibitory neurotransmitter)
- Acts on benzodiazepine receptors in CNS
Contraindications
- Hypersensitivity to prazepam or benzodiazepines
- Acute narrow-angle glaucoma
- Myasthenia gravis
- Severe respiratory depression
Adverse Reactions
- Drowsiness
- Confusion
- Dizziness
- Ataxia
- Anterograde amnesia
- Dependence and withdrawal symptoms with long-term use
Drug Interactions
- Increased sedation with CNS depressants (e.g., opioids, barbiturates, alcohol)
- Reduced efficacy of prazepam with rifampicin, phenytoin, and carbamazepine
- Increased risk of respiratory depression with concomitant opioid use
Curated Content: Needs Vetting Before Put to Clinical Use