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NERVOUS SYSTEM › PSYCHOLEPTICS › ANXIOLYTICS › Benzodiazepine derivatives
camazepam
N05BA15
Forms & Strengths
- Tablets: 10mg, 20mg
- Suppository: 10mg, 20mg
- Injectable: 5mg/mL, 10mg/mL
Adult Dosing
- Anxiety: 10-20mg PO tid-qid
- Insomnia: 10-20mg PO qhs
- Seizure disorders: 10-30mg PO tid
Pediatric Dosing
- Not recommended under 6 years old
- Anxiety, insomnia: 0.1-0.3mg/kg/d PO divided tid-qid (6-12 years old)
Indications
- Anxiety disorders
- Insomnia
- Seizure disorders (as adjunct therapy)
- Alcohol withdrawal symptoms
Mechanism of Action
- Potentiates GABA effects
- Binds to GABA_A receptors
- Enhances chloride ion influx
Contraindications
- Hypersensitivity to camazepam
- Pregnancy, especially during the first trimester
- Breastfeeding
- Severe hepatic or renal impairment
Adverse Reactions
- Drowsiness
- Dizziness
- Ataxia
- Confusion
- Dependence
- Withdrawal symptoms
Drug Interactions
- CNS depressants: additive sedative effects
- Alcohol: increased sedation, impaired coordination
- Theophylline: decreased theophylline clearance
Curated Content: Needs Vetting Before Put to Clinical Use