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NERVOUS SYSTEM › PSYCHOLEPTICS › ANXIOLYTICS › Benzodiazepine derivatives
fludiazepam
N05BA17
Forms & Strengths
- Capsules: 10mg
- Tablets: 10mg, 20mg
- Injectable: 1mg/mL, 2mg/mL
Adult Dosing
- Anxiety: 10-20mg PO tid
- Insomnia: 10-20mg PO qhs
- Seizure disorders: 10-40mg PO tid
Pediatric Dosing
- 0.1-0.2mg/kg PO tid for anxiety or seizure disorders
- Not recommended for pediatric insomnia
Indications
- Anxiety disorders
- Insomnia
- Seizure disorders
- Muscle relaxation
Mechanism of Action
- Potentiation of GABA neurotransmission
- Enhancement of benzodiazepine receptor binding
Contraindications
- Hypersensitivity to benzodiazepines
- Pregnancy and lactation
- Acute narrow-angle glaucoma
Adverse Reactions
- Drowsiness
- Dizziness
- Ataxia
- Memory impairment
- Respiratory depression
Drug Interactions
- CNS depressants: additive sedative effects
- Opioids: increased risk of respiratory depression
- CYP3A4 inhibitors: increased fludiazepam levels
Curated Content: Needs Vetting Before Put to Clinical Use