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NERVOUS SYSTEM › PSYCHOLEPTICS › ANXIOLYTICS › Diphenylmethane derivatives
hydroxyzine
N05BB01
Forms & Strengths
- Tablets: 10mg, 25mg, 50mg
- Oral solution: 10mg/5mL, 25mg/5mL
- Injectable: 25mg/mL, 50mg/mL
Adult Dosing
- Anxiety and tension: 50-100mg QID
- Sedation: 25-100mg at bedtime
- Pruritus: 25mg TID
Pediatric Dosing
- Anxiety and tension (6-12 years): 10-50mg TID
- Sedation (6-12 years): 10-50mg at bedtime
- Pruritus (6-12 years): 10-25mg TID
Indications
- Anxiety and tension
- Sedation
- Pruritus due to allergic conditions
- Nausea and vomiting
- Insomnia
Mechanism of Action
- Selective histamine H1 receptor antagonist
- Central nervous system depressant effects
- Blocks acetylcholine release in the brain
Contraindications
- Hypersensitivity to hydroxyzine or cetirizine
- Narrow-angle glaucoma
- Urinary retention
- Pregnancy and breastfeeding (use with caution)
Adverse Reactions
- Drowsiness
- Dry mouth
- Dizziness
- Headache
- Constipation
- Urinary retention
Drug Interactions
- CNS depressants (e.g., alcohol, benzodiazepines): additive sedative effects
- Opioids: increased risk of respiratory depression
- MAOIs: increased risk of hypertensive crisis
- Sedating antihistamines: additive sedative effects
Curated Content: Needs Vetting Before Put to Clinical Use