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NERVOUS SYSTEM › PSYCHOLEPTICS › HYPNOTICS AND SEDATIVES › Barbiturates, plain
thiopental
N05CA19
Forms & Strengths
- Powder for injection 1000mg
- Solution for injection 25mg/mL
Adult Dosing
- Induction of anesthesia: 3-7 mg/kg IV
- Sedation for short procedures: 1-2 mg/kg IV
Pediatric Dosing
- Neonates: 2-4 mg/kg IV
- Infants and children: 5-8 mg/kg IV
Indications
- Induction and maintenance of general anesthesia
- Sedation for short medical procedures
Mechanism of Action
- GABA receptor agonist, enhancing inhibitory neurotransmission
- Decreases cerebral metabolic rate and cerebral blood flow
Contraindications
- Porphyria
- Severe liver disease
- Adrenal insufficiency
Adverse Reactions
- Hypotension
- Apnea
- Cardiovascular collapse
- Anaphylaxis
Drug Interactions
- Opioids: additive respiratory depression
- Benzodiazepines: enhanced sedative effects
- Vasopressors: may be required to counteract hypotension
Curated Content: Needs Vetting Before Put to Clinical Use