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NERVOUS SYSTEM › PSYCHOLEPTICS › HYPNOTICS AND SEDATIVES › Barbiturates, plain
proxibarbal
N05CA22
Forms & Strengths
- oral solution
- scored tablets 250mg
- scored tablets 500mg
Adult Dosing
- 20-50 mg orally before sleep
- dosage may vary based on patient response
- maximum dose: 100mg
Pediatric Dosing
- not recommended under 6 years old
- 6-12 years: initial dose 5mg at bedtime
- dosage may be increased based on clinical response
Indications
- short-term treatment of insomnia
- sedation in diagnostic procedures
Mechanism of Action
- GABA receptor agonist
- increases chloride ion influx
- enhances sedative and hypnotic effects
Contraindications
- hypersensitivity to barbiturates
- porphyria
- severe respiratory depression
Adverse Reactions
- drowsiness
- dizziness
- residual sedation
- dependence and withdrawal
- rash and allergic reactions
Drug Interactions
- CNS depressants: additive effects
- alcohol: increased sedation
- MAOIs: enhanced sedation and hypotension
Curated Content: Needs Vetting Before Put to Clinical Use