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NERVOUS SYSTEM › PSYCHOLEPTICS › HYPNOTICS AND SEDATIVES › Aldehydes and derivatives
acetylglycinamide chloral hydrate
N05CC03
Forms & Strengths
- Capsules: 500mg, 750mg
- Tablets: 500mg
Adult Dosing
- 500mg to 1000mg at bedtime
- Maximum dose: 2000mg
Pediatric Dosing
- Not recommended for children under 12 years
- 12 years and older: 500mg at bedtime
Indications
- Short-term treatment of insomnia
- Sedation before surgical or medical procedures
Mechanism of Action
- Central nervous system depressant
- Increases GABA activity
- Decreases neural activity
Contraindications
- Hypersensitivity to chloral hydrate
- Severe liver or kidney disease
- Porous or ulcerated gastric mucosa
Adverse Reactions
- Drowsiness
- Headache
- Gastrointestinal irritation
- Allergic reactions
Drug Interactions
- Alcohol: increased sedation
- Antidepressants: increased risk of side effects
- Sedatives: additive CNS depression
Curated Content: Needs Vetting Before Put to Clinical Use