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NERVOUS SYSTEM › PSYCHOLEPTICS › HYPNOTICS AND SEDATIVES › Aldehydes and derivatives
paraldehyde
N05CC05
Forms & Strengths
- Solution for injection: 100%
- Oral solution: 10-20% with other solvents and flavorings
Adult Dosing
- Sedative and anticonvulsant: 1-4 mL IV/IM or 5-10 mL orally
- Status epilepticus: 10 mL IV slow push
Pediatric Dosing
- Not recommended due to safety concerns
- Alternatives recommended for children
Indications
- Severe seizures
- Status epilepticus
- Acute management of agitation
Mechanism of Action
- Inhibits neuronal activity in the brain
- Acts on GABA receptors
- Has sedative and anticonvulsant effects
Contraindications
- Porphyria
- Liver or kidney disease
- Known allergy to paraldehyde
Adverse Reactions
- Sedation
- Respiratory depression
- Hypotension
- Gastric irritation
- Tissue damage if leaked outside blood vessels
Drug Interactions
- Avoid use with barbiturates
- Caution with concomitant CNS depressants
- Increased risk of hypotension with antihypertensives
Curated Content: Needs Vetting Before Put to Clinical Use