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NERVOUS SYSTEM › PSYCHOLEPTICS › HYPNOTICS AND SEDATIVES › Benzodiazepine derivatives
estazolam
N05CD04
Forms & Strengths
- Tablet: 1mg, 2mg
- Generic and brand name formulations available
Adult Dosing
- Insomnia: 1-2mg orally once daily at bedtime
- Elderly or debilitated: 0.5-1mg orally once daily at bedtime
Pediatric Dosing
- Not recommended for children under 18 years
- Safety and efficacy not established in pediatric population
Indications
- Short-term treatment of insomnia
- Management of insomnia characterized by difficulty in maintaining sleep
Mechanism of Action
- Potentiation of GABA neurotransmission through agonism of the benzodiazepine site on GABA_A receptors
- Enhancement of chloride ion influx, resulting in neuronal hyperpolarization
Contraindications
- Hypersensitivity to estazolam or other benzodiazepines
- Pregnancy and lactation
- Acute narrow-angle glaucoma
- Severe respiratory insufficiency
Adverse Reactions
- Drowsiness
- Lightheadedness
- Ataxia
- Anterograde amnesia
- Residual daytime sedation
Drug Interactions
- Alcohol: additive sedative effects
- Opioids: increased risk of respiratory depression
- Benzodiazepines: increased risk of sedation and respiratory depression
- CNS depressants: additive sedative effects
Curated Content: Needs Vetting Before Put to Clinical Use