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NERVOUS SYSTEM › PSYCHOLEPTICS › HYPNOTICS AND SEDATIVES › Benzodiazepine derivatives
doxefazepam
N05CD12
Forms & Strengths
- Tablets: 5mg, 10mg
- Oral solution: 1mg/mL
Adult Dosing
- Anxiety: 5-10mg tid/qid
- Insomnia: 5-10mg hs
- Maximum dose: 20mg/day
Pediatric Dosing
- Not recommended under 18 years old
- Use with caution in elderly patients
Indications
- Anxiety disorders
- Insomnia
- Alcohol withdrawal symptoms
Mechanism of Action
- Potentiates GABA effects
- Enhances chloride ion conductance
- Binds to benzodiazepine receptors
Contraindications
- Hypersensitivity to doxefazepam
- Acute angle-closure glaucoma
- Severe respiratory depression
- Sleep apnea syndrome
Adverse Reactions
- Drowsiness
- Dizziness
- Headache
- Ataxia
- Memory impairment
- Dependence and withdrawal symptoms
Drug Interactions
- Alcohol: additive CNS depression
- Opioids: increased risk of respiratory depression
- Sedatives/hypnotics: potentiated sedation
- Rifampicin: decreased doxefazepam levels
Curated Content: Needs Vetting Before Put to Clinical Use