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NERVOUS SYSTEM › PSYCHOLEPTICS › HYPNOTICS AND SEDATIVES › Other hypnotics and sedatives
propiomazine
N05CM06
Forms & Strengths
- Tablets: 20 mg
- Solution for injection: 20 mg/mL
Adult Dosing
- Insomnia: 20-40 mg orally at bedtime
- Premedication before surgery: 20-40 mg intramuscularly or intravenously 30-60 minutes before procedure
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established; use generally not recommended
Indications
- Short-term management of insomnia
- Preoperative sedation and premedication
Mechanism of Action
- Phenothiazine derivative with central nervous system depressant, sedative, and antihistaminic properties
- Acts primarily as an antagonist at central dopamine (D2) and histamine (H1) receptors, contributing to sedative effects
Contraindications
- Hypersensitivity to propiomazine or other phenothiazines
- Acute alcohol intoxication or overdose from CNS depressants
- Comatose states or severe central nervous system depression
- History of neuroleptic malignant syndrome
Adverse Reactions
- Somnolence, drowsiness, and daytime hangover effect
- Dizziness, lightheadedness, and postural hypotension
- Anticholinergic effects such as dry mouth, blurred vision, and urinary retention
- Extrapyramidal symptoms with prolonged use or high doses
- Paradoxical excitement or restlessness in elderly patients
Drug Interactions
- Potentiation of central nervous system depression when combined with alcohol, opioids, barbiturates, or other sedatives
- Increased risk of hypotension and sedation when co-administered with antihypertensive agents
- Enhanced anticholinergic adverse effects when used alongside other drugs with anticholinergic properties
- May lower the seizure threshold, antagonizing the effects of anticonvulsants
Curated Content: Needs Vetting Before Put to Clinical Use