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NERVOUS SYSTEM › PSYCHOLEPTICS › HYPNOTICS AND SEDATIVES › Other hypnotics and sedatives
ethchlorvynol
N05CM08
Forms & Strengths
- Capsules: 200 mg
- Capsules: 500 mg
- Capsules: 750 mg
Adult Dosing
- Insomnia: 500 mg to 1000 mg orally once daily at bedtime
- Maximum recommended dose: 1000 mg per day
- Short-term use only, typically not exceeding 1 week
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Short-term treatment of insomnia (generally up to one week)
Mechanism of Action
- Short-acting sedative-hypnotic structurally related to CNS depressants
- Enhances GABA-mediated neuronal inhibition in the central nervous system
Contraindications
- Hypersensitivity to ethchlorvynol
- Porphyria
Adverse Reactions
- Dizziness
- Hangover effect
- Nausea and vomiting
- Ataxia
- Hypotension
- Paradoxical excitement or euphoria
- Prolonged use leads to tolerance, psychological dependence, and physical dependence
Drug Interactions
- Central nervous system depressants (alcohol, barbiturates, opioids, tricyclic antidepressants): potentiation of CNS depression and respiratory depression
- Coumarin anticoagulants: may decrease anticoagulant response
Curated Content: Needs Vetting Before Put to Clinical Use