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NERVOUS SYSTEM › PSYCHOLEPTICS › HYPNOTICS AND SEDATIVES › Other hypnotics and sedatives
hexapropymate
N05CM10
Forms & Strengths
- Historical sedative-hypnotic agent
- Availability varied by region, primarily as oral tablets
Adult Dosing
- Historical use for insomnia and anxiety
- Typical dosing generally ranged within established non-barbiturate sedative parameters, though largely obsolete in modern practice
Pediatric Dosing
- Not recommended or established for pediatric use
Indications
- Short-term management of insomnia
- Adjunctive treatment for anxiety states (historical)
Mechanism of Action
- Central nervous system (CNS) depression similar to other carbamate and non-barbiturate sedative-hypnotics
- Enhances GABAergic neurotransmission leading to sedative and hypnotic effects
Contraindications
- Hypersensitivity to hexapropymate or related carbamates
- Acute porphyria
- Severe respiratory depression
- Severe hepatic impairment
Adverse Reactions
- Drowsiness and daytime sedation
- Dizziness and ataxia
- Paradoxical CNS excitation
- Respiratory depression in high doses
- Risk of dependence and withdrawal syndrome with prolonged use
Drug Interactions
- Additive CNS depression with alcohol, opioids, benzodiazepines, and other sedatives
- Potentiation of sedative effects by other psychotropic medications
Curated Content: Needs Vetting Before Put to Clinical Use