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NERVOUS SYSTEM › PSYCHOLEPTICS › HYPNOTICS AND SEDATIVES › Other hypnotics and sedatives
methylpentynol
N05CM15
Forms & Strengths
- Oral capsules 250 mg
- Oral liquid formulations historically available
Adult Dosing
- Insomnia: 250 mg to 500 mg orally 15 to 30 minutes before bedtime
- Sedation: 250 mg orally 2 to 3 times daily as needed
Pediatric Dosing
- Safety and efficacy not established in pediatric patients
- Use generally avoided in children
Indications
- Short-term management of insomnia
- Anxiety and mild sedation (historical use)
Mechanism of Action
- Acts as a central nervous system depressant
- Enhances GABAergic neurotransmission similar to barbiturates and alcohols
Contraindications
- Hypersensitivity to methylpentynol or component excipients
- Severe hepatic impairment
- Respiratory depression or acute pulmonary insufficiency
- History of substance abuse or dependence
Adverse Reactions
- Drowsiness and somnolence
- Ataxia and dizziness
- Hangover effect
- Respiratory depression in high doses
- Dependence and tolerance with chronic use
Drug Interactions
- CNS depressants (alcohol, opioids, benzodiazepines, barbiturates): potentiation of sedative and respiratory depressant effects
- Hepatic enzyme inducers or inhibitors may alter metabolism
Curated Content: Needs Vetting Before Put to Clinical Use