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NERVOUS SYSTEM › PSYCHOLEPTICS › HYPNOTICS AND SEDATIVES › Hypnotics and sedatives in combination, excl. barbiturates
methylpentynol, combinations
N05CX03
Forms & Strengths
- Combination oral capsules/tablets containing methylpentynol and adjunct sedatives
- Historic formulations varied by region; largely obsolete in modern clinical practice
Adult Dosing
- Historically used as a sedative-hypnotic: 250 mg to 500 mg orally prior to sleep or medical procedures
- Combination products dosed per specific manufacturer labeling for short-term sedation and anxiety relief
Pediatric Dosing
- Safety and efficacy in pediatric patients not established
- Use generally contraindicated in children due to potential for severe CNS depression and lack of clinical data
Indications
- Historic use for short-term management of insomnia
- Historic use for mild anxiety and as a pre-anesthetic sedative
Mechanism of Action
- Acts as a central nervous system depressant
- Enhances gamma-aminobutyric acid (GABA) inhibitory neurotransmission similarly to barbiturates and alcohol
Contraindications
- Hypersensitivity to methylpentynol or any component of the formulation
- Severe respiratory depression
- Acute porphyria
- Concurrent use with alcohol or other central nervous system depressants
Adverse Reactions
- Drowsiness, dizziness, and ataxia
- Paradoxical excitation or confusion
- Respiratory depression at high doses
- Risk of physical and psychological dependence with prolonged use
Drug Interactions
- CNS depressants (alcohol, opioids, benzodiazepines, barbiturates): potentiation of sedative and respiratory depressant effects
- Anesthetics: enhanced depth of anesthesia and prolonged recovery time
Curated Content: Needs Vetting Before Put to Clinical Use