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NERVOUS SYSTEM › PSYCHOANALEPTICS › ANTIDEPRESSANTS › Selective serotonin reuptake inhibitors
zimeldine
N06AB02
Forms & Strengths
- Oral capsules 50 mg
- Oral capsules 100 mg
Adult Dosing
- Major depressive disorder: Initially 50 to 100 mg orally twice daily
- Maintenance: Titrated up to 200 mg to 300 mg daily in divided doses
Pediatric Dosing
- Safety and efficacy in pediatric patients not established
Indications
- Treatment of major depressive disorder
Mechanism of Action
- Selective serotonin reuptake inhibitor (SSRI)
- Potently and selectively inhibits the neuronal reuptake of serotonin (5-HT) with minimal effect on norepinephrine or dopamine uptake
Contraindications
- Concomitant use with monoamine oxidase inhibitors (MAOIs)
- Known hypersensitivity to zimeldine
Adverse Reactions
- Guillain-Barré syndrome (led to worldwide withdrawal)
- Nausea
- Dry mouth
- Insomnia
- Dizziness
- Headache
- Hypersensitivity reactions including skin rash and myalgia
Drug Interactions
- Monoamine oxidase inhibitors (MAOIs): Risk of severe, potentially fatal serotonin syndrome
- Central nervous system depressants: Potential for enhanced sedative effects
Curated Content: Needs Vetting Before Put to Clinical Use