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NERVOUS SYSTEM › PSYCHOANALEPTICS › ANTIDEPRESSANTS › Selective serotonin reuptake inhibitors
etoperidone
N06AB09
Forms & Strengths
- Oral tablets: 50 mg
- Oral tablets: 100 mg
Adult Dosing
- Initial: 50 mg to 100 mg orally once daily, usually at bedtime
- Maintenance: 100 mg to 300 mg daily in divided doses or as a single bedtime dose
- Maximum daily dose: 400 mg
Pediatric Dosing
- Safety and efficacy not established in pediatric patients under 18 years
Indications
- Treatment of major depressive disorder
- Depression accompanied by anxiety
Mechanism of Action
- Serotonin 5-HT2 receptor antagonist
- Inhibits neuronal reuptake of serotonin and norepinephrine
- Weak alpha-1 adrenergic receptor antagonist
Contraindications
- Hypersensitivity to etoperidone or phenylpiperazine derivatives
- Acute recovery phase following myocardial infarction
- Concomitant use with MAO inhibitors
Adverse Reactions
- Somnolence and sedation
- Dizziness and orthostatic hypotension
- Dry mouth and nausea
- Headache
- Rare risk of priapism
Drug Interactions
- CYP3A4 inhibitors (e.g., ketoconazole) may increase etoperidone plasma concentrations
- CNS depressants and alcohol enhance sedative effects
- Antihypertensive agents may cause additive hypotensive effects
- MAO inhibitors increase risk of serotonin syndrome
Curated Content: Needs Vetting Before Put to Clinical Use