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NERVOUS SYSTEM › PSYCHOANALEPTICS › ANTIDEPRESSANTS › Other antidepressants
bifemelane
N06AX08
Adult Dosing
- 50 mg orally three times daily after meals
- Dose may be adjusted based on age and clinical symptoms
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Improvement of cerebral infarction symptoms
- Improvement of psychiatric symptoms associated with cerebrovascular disease
Mechanism of Action
- Inhibits monoamine oxidase (MAO) A and B
- Increases brain concentrations of norepinephrine, serotonin, and dopamine
- Exerts neuroprotective effects against cerebral ischemia and hypoxia
Contraindications
- Hypersensitivity to bifemelane or any component of the formulation
- Severe hepatic impairment
- Concurrent use with monoamine oxidase inhibitors (MAOIs)
Adverse Reactions
- Insomnia
- Dizziness
- Headache
- Gastrointestinal distress (nausea, stomach discomfort, anorexia)
- Elevated liver enzymes
- Rash
Drug Interactions
- Monoamine oxidase inhibitors (MAOIs): potential risk of hypertensive crisis or CNS excitation
- L-DOPA: may enhance dopaminergic effects
- Antihypertensive agents: potential for enhanced blood pressure lowering
Curated Content: Needs Vetting Before Put to Clinical Use