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NERVOUS SYSTEM › PSYCHOANALEPTICS › ANTIDEPRESSANTS › Other antidepressants
medifoxamine
N06AX13
Forms & Strengths
- Oral capsules 50 mg
- Oral tablets 100 mg
Adult Dosing
- Major depressive disorder: 100 mg to 300 mg daily in divided doses
- Initial dose typically 50 mg to 100 mg daily, titrated upward based on clinical response and tolerability
Pediatric Dosing
- Safety and efficacy in pediatric patients under 18 years not established
Indications
- Major depressive disorder
Mechanism of Action
- Atypical antidepressant acting primarily as a serotonin and noradrenaline reuptake inhibitor (SNRI)
- Displays weak affinity for monoamine receptors, modulating central monoaminergic neurotransmission
Contraindications
- Hypersensitivity to medifoxamine or any component of the formulation
- Concurrent use with monoamine oxidase inhibitors (MAOIs) due to risk of serotonin syndrome
- Severe hepatic impairment
Adverse Reactions
- Nausea and dry mouth
- Drowsiness and fatigue
- Insomnia and agitation
- Dizziness and headache
- Constipation and gastrointestinal discomfort
Drug Interactions
- Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis and serotonin syndrome
- Central nervous system depressants (alcohol, sedatives, hypnotics): enhanced sedative effects
- Serotonergic agents (SSRIs, SNRIs, triptans): increased risk of serotonin toxicity
Curated Content: Needs Vetting Before Put to Clinical Use