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NERVOUS SYSTEM › PSYCHOANALEPTICS › ANTIDEPRESSANTS › Other antidepressants
vilazodone
N06AX24
Forms & Strengths
- Oral tablets: 10 mg
- Oral tablets: 20 mg
- Oral tablets: 40 mg
Adult Dosing
- Initial: 10 mg orally once daily for 7 days
- Titration: Increase to 20 mg orally once daily for 7 days
- Maintenance: 20 mg to 40 mg orally once daily with food
- Maximum dose: 40 mg once daily
Pediatric Dosing
- Safety and efficacy not established in pediatric patients < 18 years
Indications
- Major Depressive Disorder (MDD) in adults
Mechanism of Action
- Selective serotonin reuptake inhibitor (SSRI)
- 5-HT1A partial agonist
Contraindications
- Concomitant monoamine oxidase inhibitors (MAOIs) or use within 14 days
- Initiation in patients receiving linezolid or intravenous methylene blue
- Known hypersensitivity to vilazodone
Adverse Reactions
- Diarrhea
- Nausea
- Vomiting
- Insomnia
- Dizziness
- Dry mouth
- Fatigue
Drug Interactions
- MAOIs (risk of serotonin syndrome)
- Strong CYP3A4 inhibitors (reduce vilazodone dose to 20 mg)
- Strong CYP3A4 inducers (avoid coadministration)
- Serotonergic drugs like SSRIs, SNRIs, triptans (increased risk of serotonin syndrome)
- Drugs that impair hemostasis, such as NSAIDs, aspirin, warfarin (increased bleeding risk)
Curated Content: Needs Vetting Before Put to Clinical Use