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NERVOUS SYSTEM › PSYCHOANALEPTICS › PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS › Other psychostimulants and nootropics
meclofenoxate
N06BX01
Forms & Strengths
- Oral capsules: 250 mg
- Oral tablets: 100 mg, 250 mg
Adult Dosing
- Cognitive impairment/dementia: 250 mg to 500 mg orally 3 times daily
- Maximum daily dose: 1.5 g
Pediatric Dosing
- Safety and efficacy not established in pediatric patients
Indications
- Senile dementia
- Cognitive impairment and memory disorders
- Cerebrovascular insufficiency sequelae
- Alcohol withdrawal syndrome
Mechanism of Action
- Centrally acting nootropic agent and cholinergic enhancer
- Esters of dimethylaminoethanol (DMAE) and parachlorophenoxyacetate (pCPA)
- Increases synthesis and uptake of acetylcholine in the brain
- Exhibits antioxidant properties and reduces lipofuscin accumulation in neurons
Contraindications
- Hypersensitivity to meclofenoxate or any component
- Severe hypertension
- Hyperexcitability states or severe anxiety
Adverse Reactions
- Insomnia
- Agitation and restlessness
- Nausea and gastrointestinal distress
- Dizziness
- Skin rash
Drug Interactions
- Central nervous system stimulants (may potentiate excitation)
- Anticholinesterases (may have additive cholinergic effects)
- Levodopa (may reduce efficacy or alter movement disorders)
Curated Content: Needs Vetting Before Put to Clinical Use