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NERVOUS SYSTEM › PSYCHOANALEPTICS › PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS › Other psychostimulants and nootropics
citicoline
N06BX06
Forms & Strengths
- Oral Solution: 100 mg/mL
- Oral Tablet: 500 mg, 1000 mg
- Solution for Injection: 250 mg/mL, 500 mg/4 mL
Adult Dosing
- Cerebrovascular disease / stroke: 500 mg to 2000 mg daily orally or via IV/IM injection, divided in 1 to 2 doses.
- Cognitive impairment / neurodegeneration: 500 mg to 1000 mg daily orally, divided in 1 to 2 doses.
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established; use is generally not recommended.
Indications
- Supportive treatment of cognitive impairment associated with cerebrovascular disease and traumatic brain injury.
- Adjunctive therapy in acute ischemic stroke.
Mechanism of Action
- Acts as an exogenous source of cytidine and choline, intermediates in the biosynthesis of phosphatidylcholine (lecithin), a major neuronal cell membrane phospholipid.
- Increases brain neurotransmitter levels (acetylcholine, dopamine, norepinephrine) and protects neuronal membranes against ischemia-induced degradation.
Contraindications
- Hypersensitivity to citicoline or any component of the formulation.
- Patients with hypertonia of the parasympathetic nervous system.
Adverse Reactions
- Insomnia
- Headache
- Gastrointestinal distress (diarrhea, nausea, abdominal pain)
- Hypotension or hypertension (transient)
- Blurred vision
Drug Interactions
- L-Dopa: Citicoline potentiates the effects of L-dopa, which may be beneficial in Parkinson's disease but requires monitoring.
- Meclofenoxate: Concurrent use should be avoided as it may enhance adverse effects.
- Centrally acting anticholinergics: May theoretically antagonize pharmacodynamic effects.
Curated Content: Needs Vetting Before Put to Clinical Use