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oxiracetam

N06BX07

Forms & Strengths

Oral capsules: 400 mg
Oral powder / sachets: 800 mg, 1500 mg
Oral solution: 10%

Adult Dosing

Cognitive impairment / memory disorders: 800 mg to 1200 mg orally twice daily (total daily dose 1600 mg - 2400 mg)
Maximum daily dose: 2400 mg divided into two or three doses

Pediatric Dosing

Safety and efficacy in pediatric patients have not been established; use is generally not recommended

Indications

Cognitive enhancement and memory deficit treatment
Age-related cognitive decline
Dementia and cerebrovascular insufficiency (off-label or regional approvals in Europe/Asia)

Mechanism of Action

Pyrrolidone derivative and nootropic agent
Modulates cholinergic neurotransmission via high-affinity choline uptake enhancement
Potentiates AMPA-type glutamate receptors, facilitating long-term potentiation (LTP)
Increases protein kinase C (PKC) activity in the hippocampus

Contraindications

Hypersensitivity to oxiracetam, other racetam derivatives, or any component of the formulation
Severe renal impairment (creatinine clearance < 20 mL/min)
Severe hepatic impairment
Active cerebral hemorrhage or hemorrhagic stroke

Adverse Reactions

Insomnia and sleep disturbances
Agitation, irritability, and anxiety
Headache and dizziness
Nausea, gastrointestinal distress, and dyspepsia
Psychomotor agitation (primarily at high doses)

Drug Interactions

CNS stimulants: may potentiate stimulatory effects and risk of insomnia or agitation
Anticoagulants / Antiplatelets: theoretical risk of bleeding enhancement (use with caution)
No significant inhibition or induction of major hepatic cytochrome P450 enzymes identified

Curated Content: Needs Vetting Before Put to Clinical Use