← Search & browse all drugs
NERVOUS SYSTEM › PSYCHOANALEPTICS › PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS › Other psychostimulants and nootropics
linopirdine
N06BX09
Forms & Strengths
- Experimental investigational pharmaceutical formulations
Adult Dosing
- Not applicable; investigated previously in clinical trials for cognitive impairment and Alzheimer's disease at variable doses (e.g., 10 mg to 30 mg orally daily to multiple times daily), but not approved for clinical use.
Pediatric Dosing
- No established pediatric dosing; not indicated for pediatric patients.
Indications
- Investigated historically for the treatment of cognitive deficits and Alzheimer's disease (development discontinued)
Mechanism of Action
- Selective blocker of voltage-dependent potassium channels (M-current blocker)
- Enhances acetylcholine release in the cerebral cortex and hippocampus
Contraindications
- Hypersensitivity to linopirdine or its excipients
- History of seizure disorders or conditions lowering seizure threshold (theoretical concern due to M-channel blockade)
Adverse Reactions
- Dizziness
- Headache
- Somnolence
- Insomnia
- Gastrointestinal disturbances (nausea, dyspepsia)
- Agitation
Drug Interactions
- Potential risk of pharmacodynamic interactions with other central nervous system stimulants or seizure-threshold lowering agents
- No widely established clinical drug-interaction profile due to discontinuation of development
Curated Content: Needs Vetting Before Put to Clinical Use