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NERVOUS SYSTEM › PSYCHOANALEPTICS › PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS › Other psychostimulants and nootropics
prolintane
N06BX14
Forms & Strengths
- Oral tablets: 10 mg
- Combination preparations with vitamins or other stimulants (historical/regional)
Adult Dosing
- 10 mg to 20 mg orally once to twice daily in the morning and early afternoon
- Avoid late afternoon or evening administration to prevent insomnia
Pediatric Dosing
- Safety and efficacy not established in pediatric patients
- Not recommended for use in children or adolescents
Indications
- Management of chronic fatigue, asthenia, and apathy
- Adjunctive treatment of mild depressive states (historical or regional usage)
Mechanism of Action
- Indirect-acting sympathomimetic amine
- Inhibits the neuronal reuptake of dopamine and norepinephrine, increasing their synaptic concentrations in the central nervous system
Contraindications
- Known hypersensitivity to prolintane or other sympathomimetic amines
- Severe hypertension or cardiovascular disease
- Hyperthyroidism
- Glaucoma
- Concomitant use with MAO inhibitors or within 14 days of discontinuation
- History of severe anxiety, agitation, or psychosis
Adverse Reactions
- Insomnia
- Tachycardia and palpitations
- Elevated blood pressure
- Anxiety, nervousness, and restlessness
- Dry mouth and decreased appetite
- Tremors
Drug Interactions
- Monoamine oxidase inhibitors (MAOIs): Risk of hypertensive crisis
- Sympathomimetic agents and vasopressors: Potentiation of cardiovascular effects
- Antihypertensives: Decreased efficacy of blood pressure-lowering medications
- General anesthetics: Increased risk of cardiac arrhythmias
Curated Content: Needs Vetting Before Put to Clinical Use