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NERVOUS SYSTEM › PSYCHOANALEPTICS › PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS › Other psychostimulants and nootropics
pipradrol
N06BX15
Forms & Strengths
- Oral tablets: 1 mg, 2 mg
- Extended-release formulations (historical)
Adult Dosing
- Depression or lethargy: 1 to 2 mg orally once to three times daily
- Maximum recommended daily dose: 6 mg
Pediatric Dosing
- Not recommended or established for routine pediatric use
- Safety and efficacy in children under 12 years have not been adequately studied
Indications
- Adjunctive treatment of emotional fatigue, lethargy, and mild depressive states
- Historically used as a central nervous system stimulant
Mechanism of Action
- Central nervous system stimulant
- Inhibits the reuptake of norepinephrine and dopamine
- Minimal peripheral sympathomimetic activity compared to amphetamines
Contraindications
- Known hypersensitivity to pipradrol
- Agitated states, severe anxiety, or tension
- Glaucoma
- Concurrent use with monoamine oxidase inhibitors (MAOIs)
Adverse Reactions
- Insomnia
- Nervousness, anxiety, and agitation
- Tachycardia and palpitations
- Dry mouth
- Tremors
Drug Interactions
- Monoamine oxidase inhibitors (MAOIs): Risk of hypertensive crisis and severe central nervous system excitation
- Sympathomimetic agents: Potentiation of cardiovascular and central nervous system stimulant effects
- Central nervous system depressants: Antagonism of sedative effects
Curated Content: Needs Vetting Before Put to Clinical Use