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NERVOUS SYSTEM › OTHER NERVOUS SYSTEM DRUGS › DRUGS USED IN ADDICTIVE DISORDERS › Drugs used in alcohol dependence
calcium carbimide
N07BB02
Adult Dosing
- Initial: 50 to 100 mg daily given as a single dose
- Maintenance: 50 mg daily (range 50 to 150 mg daily)
- Maximum daily dose: 150 mg
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Adjunctive treatment for chronic alcoholism to support abstinence through deterrence via acetaldehyde syndrome upon alcohol ingestion
Mechanism of Action
- Aldehyde dehydrogenase inhibitor
- Blocks the metabolism of acetaldehyde resulting in its rapid accumulation in the blood following alcohol consumption, causing unpleasant vasomotor symptoms (flushing, nausea, tachycardia, hypotension)
Contraindications
- Hypersensitivity to calcium carbimide or any component
- Recent or concurrent ingestion of alcohol-containing products
- Severe myocardial disease or coronary occlusion
- Severe psychiatric disorders
- Pregnancy and lactation
Adverse Reactions
- Fatigue
- Drowsiness
- Dizziness
- Skin rash
- Tinnitus
- Anorexia
- Acetaldehyde-ethanol reaction symptoms upon alcohol ingestion (flushing, palpitations, dyspnea, nausea, vomiting, headache)
Drug Interactions
- Ethanol: Provokes severe disulfiram-like acetaldehyde reaction
- Paraldehyde: Should not be administered concurrently
- Metronidazole: May cause acute toxic psychosis or confusion when combined with aldehyde dehydrogenase inhibitors
Curated Content: Needs Vetting Before Put to Clinical Use