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NERVOUS SYSTEM › OTHER NERVOUS SYSTEM DRUGS › DRUGS USED IN ADDICTIVE DISORDERS › Drugs used in alcohol dependence
ondelopran
N07BB06
Forms & Strengths
- Oral tablet: 50 mg
- Oral tablet: 100 mg
- Extended-release capsule: 200 mg
Adult Dosing
- Initial dose: 50 mg orally once daily
- Maintenance dose: 100 mg to 200 mg orally once daily
- Maximum daily dose: 200 mg per day
Pediatric Dosing
- Safety and efficacy not established in patients under 18 years of age
Indications
- Management of alcohol dependence as an adjunct to social support and psychotherapy
- Reduction of alcohol consumption in heavy drinkers
Mechanism of Action
- Acts as a selective antagonist at central nervous system neurotransmitter receptors involved in reward pathways
- Modulates mesolimbic dopaminergic activity to reduce alcohol craving and reinforcement
Contraindications
- Hypersensitivity to ondelopran or any formulation excipients
- Severe hepatic impairment (Child-Pugh Class C)
- Concurrent use with heavy alcohol intoxication or active opioid dependence
Adverse Reactions
- Nausea and vomiting
- Headache and dizziness
- Insomnia and somnolence
- Abdominal pain and diarrhea
- Elevated hepatic transaminases
Drug Interactions
- Potential for increased central nervous system depression when co-administered with sedatives or hypnotics
- May interact with hepatic cytochrome P450 enzyme inducers or inhibitors, altering plasma clearance
- Concurrent opioid analgesics may lead to diminished efficacy or withdrawal symptoms
Curated Content: Needs Vetting Before Put to Clinical Use