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tirilazad
N07XX01
Forms & Strengths
- Intravenous solution: 2 mg/mL, 5 mg/mL
Adult Dosing
- Subarachnoid hemorrhage: 6 mg/kg/day IV administered in divided doses every 6 hours for up to 3 to 10 days
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Investigationally studied for the reduction of secondary ischemic damage in aneurysmal subarachnoid hemorrhage
Mechanism of Action
- Nonglucocorticoid 21-aminosteroid (lazaroid)
- Potent lipid peroxidation inhibitor and scavenger of oxygen free radicals
- Protects cell membranes from oxidative degradation during cerebral ischemia
Contraindications
- Hypersensitivity to tirilazad or any component of the formulation
- Concomitant administration with certain interacting enzyme inducers depending on regional approvals
Adverse Reactions
- Injection site reactions
- Nausea and vomiting
- Hypertension or hypotension
- Elevated liver function tests
- Fever
Drug Interactions
- Inducers of CYP3A4 (e.g., phenytoin, carbamazepine, phenobarbital) may decrease tirilazad plasma concentrations
- Inhibitors of CYP3A4 may increase tirilazad exposure
Curated Content: Needs Vetting Before Put to Clinical Use