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amifampridine

N07XX05

Forms & Strengths

10mg tablets

Adult Dosing

Initial dose 10mg twice daily
Titrate by 10mg daily every 3-7 days as needed and tolerated
Maximum dose 60mg daily

Pediatric Dosing

Not established

Indications

Treatment of Lambert-Eaton Myasthenic Syndrome (LEMS)
Treatment of multiply sclerosis related walking disability

Mechanism of Action

Inhibits potassium channels at the nerve terminal
Increases release of acetylcholine

Contraindications

Hypersensitivity to amifampridine
History of seizures

Adverse Reactions

Paresthesia
Seizures
Abdominal pain
Nausea
Diarrhea

Drug Interactions

Concurrent treatment with drugs that lower seizure threshold may increase seizure risk

Curated Content: Needs Vetting Before Put to Clinical Use