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NERVOUS SYSTEM › OTHER NERVOUS SYSTEM DRUGS › OTHER NERVOUS SYSTEM DRUGS › Other nervous system drugs
pridopidine
N07XX26
Forms & Strengths
- Oral capsules: 22.5 mg
- Oral capsules: 45 mg
Adult Dosing
- Huntington's disease: 45 mg orally twice daily
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Treatment of motor function impairment associated with Huntington's disease
Mechanism of Action
- Highly selective sigma-1 receptor (S1R) agonist
- Enhances neuroprotective pathways and restores synaptic plasticity
- Modulates dopaminergic and glutamatergic neurotransmission
Contraindications
- Hypersensitivity to pridopidine or any formulation excipients
Adverse Reactions
- Nasopharyngitis
- Insomnia
- Falls
- Diarrhea
- Fatigue
- Headache
Drug Interactions
- CYP2D6 inhibitors may increase plasma concentrations of pridopidine
- Strong CYP3A4 inducers may decrease plasma concentrations of pridopidine
- Potential for additive CNS depression when used with other sedating agents
Curated Content: Needs Vetting Before Put to Clinical Use