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ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS › ANTIPROTOZOALS › AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES › Hydroxyquinoline derivatives
tilbroquinol
P01AA05
Adult Dosing
- Intestinal amebiasis: 250 mg orally 3 times daily for 10 days
Pediatric Dosing
- Safety and efficacy in pediatric patients not well established; use generally avoided or adjusted by weight per specialist consultation
Indications
- Treatment of intestinal amebiasis (Entamoeba histolytica)
- Intestinal antiseptic in specific protozoal infections
Mechanism of Action
- Halogenated 8-hydroxyquinoline derivative with luminal amebicidal activity
- Chelates trace metals essential for protozoal survival and inhibits parasite enzymes
Contraindications
- Hypersensitivity to 8-hydroxyquinolines or iodine derivatives
- Severe hepatic impairment
- Severe renal impairment
- History of optic neuropathy
Adverse Reactions
- Nausea
- Vomiting
- Abdominal pain
- Diarrhea
- Peripheral neuropathy (with prolonged use)
- Optic neuritis (with prolonged use)
Drug Interactions
- Antacids containing aluminum, calcium, or magnesium may decrease absorption
- Halogenated hydroxyquinolines may interfere with thyroid function test results (increases protein-bound iodine)
- Concurrent use with other neurotoxic drugs may increase risk of peripheral neuropathy
Curated Content: Needs Vetting Before Put to Clinical Use