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ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS › ANTIPROTOZOALS › AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES › Hydroxyquinoline derivatives
tilbroquinol and tiliquinol
P01AA30
Forms & Strengths
- Combined oral capsules: 200 mg (tilbroquinol 133.3 mg + tiliquinol 66.7 mg)
Adult Dosing
- Intestinal amoebiasis: 1 capsule 3 times daily with meals for 10 days
Pediatric Dosing
- Safety and efficacy not established in children; use generally not recommended
Indications
- Treatment of intestinal amoebiasis (Entamoeba histolytica)
- Amoebic dysentery
Mechanism of Action
- Halogenated 8-hydroxyquinoline derivative with luminal amebicidal activity
- Chelates trace metals essential for amoebic survival and proliferation in the intestinal lumen
Contraindications
- Hypersensitivity to 8-hydroxyquinolines or iodine derivatives
- Severe hepatic impairment
- History of optic neuropathy
Adverse Reactions
- Nausea
- Vomiting
- Abdominal pain
- Diarrhea
- Peripheral neuropathy with prolonged use
- Optic neuritis with prolonged use
Drug Interactions
- Avoid concurrent use with other hydroxyquinolines due to risk of cumulative neurotoxicity
- May chelate with metal cations (e.g., iron, magnesium, aluminum), decreasing absorption
Curated Content: Needs Vetting Before Put to Clinical Use