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ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS › ANTIPROTOZOALS › AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES › Hydroxyquinoline derivatives
clioquinol, combinations
P01AA52
Forms & Strengths
- Cream: clioquinol 3% with hydrocortisone 1% (or similar combination)
- Ointment: clioquinol 3% with hydrocortisone 1% (or similar combination)
Adult Dosing
- Apply thin layer to affected skin areas 2 to 4 times daily
- Limit duration of continuous therapy, typically not exceeding 7 to 14 days
- Avoid use under occlusive dressings unless specifically directed
Pediatric Dosing
- Children > 2 years: Apply sparingly to affected areas 2 to 3 times daily
- Use lowest effective dose and limit duration due to systemic absorption risks
- Not recommended in infants or young children
Indications
- Treatment of inflammatory dermatoses complicated by secondary bacterial or fungal infections
- Eczema, contact dermatitis, and seborrheic dermatitis with infection
Mechanism of Action
- Clioquinol exerts antibacterial and antifungal activity via chelation of trace metals essential for microbial growth
- Hydrocortisone provides anti-inflammatory, antipruritic, and vasoconstrictive effects
Contraindications
- Hypersensitivity to clioquinol, hydroxyquinoline derivatives, corticosteroids, or any excipient
- Viral skin infections (e.g., varicella, herpes simplex, vaccinia)
- Tuberculous or fungal skin lesions without concomitant anti-infective therapy
- Primary bacterial skin infections without inflammatory component
- Open wounds or denuded skin areas
Adverse Reactions
- Local burning, irritation, dryness, or pruritus at application site
- Staining of skin, hair, and clothing (yellowish discoloration)
- Systemic corticosteroid effects with prolonged use, large surface areas, or occlusion
- Skin atrophy, striae, telangiectasia, and secondary infection with prolonged topical steroid use
Drug Interactions
- May interfere with thyroid function tests (protein-bound iodine) due to iodine content
- Potential for enhanced systemic absorption when used with other topical or systemic corticosteroids
- Topical products containing heavy metals may cause incompatibilities
Curated Content: Needs Vetting Before Put to Clinical Use