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ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS › ANTIPROTOZOALS › AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES › Dichloroacetamide derivatives
teclozan
P01AC04
Forms & Strengths
- Oral suspension: 50 mg/5 mL
- Tablets: 500 mg
Adult Dosing
- Intestinal amebiasis: 500 mg orally twice daily for 3 days
Pediatric Dosing
- Children > 2 years: 5-10 mg/kg orally twice daily for 3 days
- Children < 2 years: Safety and efficacy not established
Indications
- Treatment of intestinal amebiasis caused by Entamoeba histolytica
- Amebic dysentery
Mechanism of Action
- Acts directly as a luminal amebicide in the gastrointestinal tract
- Eliminates trophozoites and cysts in the intestinal lumen without significant systemic absorption
Contraindications
- Hypersensitivity to teclozan or related dichloroacetamide derivatives
- Severe hepatic impairment
- Extra-intestinal amebiasis (e.g., liver abscess)
Adverse Reactions
- Mild gastrointestinal distress (nausea, abdominal cramps, diarrhea)
- Transient headache
- Dizziness
Drug Interactions
- No significant systemic drug interactions due to minimal systemic absorption
- Potential decreased efficacy if administered concurrently with other non-absorbed luminal agents
Curated Content: Needs Vetting Before Put to Clinical Use