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ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS › ANTIPROTOZOALS › AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES › Other agents against amoebiasis and other protozoal diseases
phanquinone
P01AX04
Adult Dosing
- Intestinal amebiasis: 250 mg orally 3 times daily for 5 to 10 days
Pediatric Dosing
- Safety and efficacy in pediatric patients not well established; use generally avoided or restricted based on age/weight under strict clinical supervision
Indications
- Treatment of intestinal amebiasis
- Treatment of various forms of infectious diarrhea and dysentery
Mechanism of Action
- Halogenated 8-hydroxyquinoline derivative with luminal amebicidal, antibacterial, and antifungal properties
- Chelates trace metals essential for parasite and bacterial enzyme systems, disrupting replication and metabolism
Contraindications
- Hypersensitivity to phanquinone or other hydroxyquinolines
- Severe hepatic impairment
- Severe renal impairment
- Pre-existing optic neuropathy or severe neurological disorders
Adverse Reactions
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Hypersensitivity skin reactions
- Subacute myelo-optic neuropathy (SMON) with prolonged or high-dose use (class effect of halogenated hydroxyquinolines)
Drug Interactions
- Antacids containing aluminum, calcium, or magnesium may decrease gastrointestinal absorption
- Oral iron supplements may chelate with the drug, reducing efficacy
- Concurrent use with other neurotoxic agents may increase risk of peripheral neuropathy
Curated Content: Needs Vetting Before Put to Clinical Use