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ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS › ANTHELMINTICS › ANTITREMATODALS › Quinoline derivatives and related substances
arpraziquantel
P02BA03
Forms & Strengths
- 400mg tablets
- 600mg tablets
Adult Dosing
- 400mg as a single dose for taeniasis
- 600mg bid for 3 days for schistosomiasis
Pediatric Dosing
- 20-30mg/kg as a single dose, max 1200mg for taeniasis
- 20-30mg/kg/day divided in 2 doses for 3 days, max 1200mg/day for schistosomiasis
Indications
- Taeniasis
- Schistosomiasis
- Neurocysticercosis
- Hookworm infections
Mechanism of Action
- Interferes with parasite's sucrose uptake
- Alters the parasite's microtubule function
- Increases the permeability of parasite cell membrane to Ca2+
Contraindications
- Hypersensitivity to arpraziquantel or its components
- Concomitant use of strong CYP3A4 inhibitors
Adverse Reactions
- Abdominal pain
- Nausea
- Vomiting
- Diarrhea
- Dizziness
- Headache
Drug Interactions
- CYP3A4 inhibitors: increase arpraziquantel levels
- CYP3A4 inducers: decrease arpraziquantel levels
- Praziquantel: concomitant use not recommended
Curated Content: Needs Vetting Before Put to Clinical Use