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ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS › ANTHELMINTICS › ANTINEMATODAL AGENTS › Benzimidazole derivatives
flubendazole
P02CA05
Forms & Strengths
- Oral suspension: 20 mg/mL
- Chewable tablet: 500 mg
Adult Dosing
- Ascariasis, Trichuriasis, Hookworm: 100 mg orally twice daily for 3 consecutive days, or a single 500 mg oral dose.
- Enterobiasis: 100 mg orally as a single dose, repeated after 2 to 4 weeks.
Pediatric Dosing
- Children >= 1 year: Same as adult dosing for Ascariasis, Trichuriasis, and Hookworm (100 mg twice daily for 3 days or 500 mg single dose).
- Enterobiasis (Children >= 1 year): 100 mg orally as a single dose, repeated after 2 to 4 weeks.
Indications
- Treatment of gastrointestinal nematode infections (Ascaris lumbricoides, Trichuris trichiura, Enterobius vermicularis, Ancylostoma duodenale, Necator americanus).
Mechanism of Action
- Binds specifically to beta-tubulin of parasites, inhibiting microtubule polymerization and preventing glucose uptake, leading to energy depletion and parasite death.
Contraindications
- Hypersensitivity to flubendazole or benzimidazole derivatives
- Pregnancy (first trimester)
Adverse Reactions
- Transient abdominal pain
- Diarrhea
- Nausea
- Headache
- Elevated liver enzymes (rare with short-term use)
Drug Interactions
- Cimetidine may inhibit the metabolism of flubendazole, increasing plasma concentrations.
- Strong CYP450 inducers (e.g., carbamazepine, phenytoin) may decrease flubendazole plasma levels.
Curated Content: Needs Vetting Before Put to Clinical Use