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potassium polysulfide

P03AA02

Forms & Strengths

Topical solution (various concentrations, typically 2-5%)
Medicated soap/ointment formulations

Adult Dosing

Apply topically to affected skin areas 1-2 times daily as directed by clinical presentation

Pediatric Dosing

Safety and efficacy in pediatric patients not well-established; use with caution and lower concentrations if deemed necessary by a clinician

Indications

Treatment of scabies (historical/alternative ectoparasiticide)
Adjunctive treatment of certain fungal skin infections and seborrheic dermatitis

Mechanism of Action

Exerts keratolytic, antipruritic, and mild parasiticide/antifungal effects through the release of active sulfur and sulfide species upon skin contact

Contraindications

Hypersensitivity to sulfur, polysulfides, or any component of the formulation
Application on broken, raw, or heavily inflamed skin

Adverse Reactions

Local skin irritation, redness, and burning
Contact dermatitis and dryness with prolonged use
Unpleasant sulfur odor

Drug Interactions

Concurrent use with other topical keratolytics or acne medications (e.g., tretinoin, benzoyl peroxide, salicylic acid) may cause severe skin irritation
Potential staining or interaction with other topical metals (e.g., silver-containing products)

Curated Content: Needs Vetting Before Put to Clinical Use