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ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS › ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS › ECTOPARASITICIDES, INCL. SCABICIDES › Sulfur containing products
thiram
P03AA05
Forms & Strengths
- Topical powder: 1%
- Topical cream/ointment: 10%
Adult Dosing
- Apply to affected skin areas once to twice daily as directed
- Duration of treatment typically depends on clinical response and condition treated
Pediatric Dosing
- Safety and efficacy in pediatric patients not well established
- Use with caution and only under direct medical supervision in children
Indications
- Treatment of fungal skin infections such as tinea infections
- Management of scabies and related parasitic skin infestations
Mechanism of Action
- Acts as a sulfur-containing parasiticide and antifungal agent
- Inhibits key enzymatic systems in dermatophytes and ectoparasites leading to cell death
Contraindications
- Hypersensitivity to thiram, disulfiram, or related thiuram compounds
- Application to broken, raw, or heavily inflamed skin surfaces
Adverse Reactions
- Local skin irritation, burning, or stinging at application site
- Contact dermatitis and allergic skin reactions
- Erythema and pruritus
Drug Interactions
- Concomitant topical alcohol-containing products may increase skin irritation
- Potential cross-sensitivity reaction with systemic disulfiram causing alcohol intolerance
Curated Content: Needs Vetting Before Put to Clinical Use