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ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS › ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS › ECTOPARASITICIDES, INCL. SCABICIDES › Chlorine containing products
clofenotane
P03AB01
Forms & Strengths
- Oral paste 0.5% w/v
- Oral solution 1% w/v
- Drinking water suspension 0.2%
- Drench 0.5 mg mL‑1
Adult Dosing
- Cattle: 0.5‑1 mg kg⁻¹ PO single dose
- Sheep: 0.5 mg kg⁻¹ PO single dose
- Goats: 0.5 mg kg⁻¹ PO single dose
Pediatric Dosing
- Lambs & calves <30 kg: 0.5 mg kg⁻¹ PO single dose (same as adults)
- Neonates <2 weeks: avoid or reduce to 0.25 mg kg⁻¹ PO
Indications
- Gastrointestinal nematodes (Haemonchus, Ostertagia, Trichostrongylus) in cattle and sheep
- Liver fluke (Fasciola hepatica) in cattle
- Ectoparasite control (fleas, lice) – off‑label
Mechanism of Action
- Irreversible inhibition of parasite acetylcholinesterase
- Accumulation of acetylcholine → spastic paralysis and death of helminths
Contraindications
- Known hypersensitivity to organophosphates
- Pregnant animals, especially first trimester
- Severely ill or liver‑compromised animals
Adverse Reactions
- Excessive salivation, lacrimation, rhinorrhea
- Diarrhea, abdominal cramps
- Muscle tremor, ataxia, convulsions
- Respiratory depression
- Transient depression of host cholinesterase
Drug Interactions
- Concurrent use of other cholinesterase inhibitors → additive toxicity
- Anticholinergics may mask cholinergic signs
- CYP450 inducers (e.g., phenobarbital) may reduce efficacy
- CYP450 inhibitors (e.g., ketoconazole) may increase toxicity
Curated Content: Needs Vetting Before Put to Clinical Use