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clofenotane, combinations

P03AB51

Forms & Strengths

Topical lotion: clofenotane (DDT) combined with active ingredients like benzyl benzoate and benzocaine
Topical liquid/spray formulations for ectoparasite eradication

Adult Dosing

Apply topically to affected skin/hair areas as directed by specific combination product labeling
Single application typically left for a specified duration (e.g., 24 hours) followed by thorough washing
Repeat application generally discouraged unless clinically indicated after 7-10 days

Pediatric Dosing

Safety and efficacy in neonates and infants not well established; avoid use in very young infants due to systemic absorption risks
For older children, apply sparingly to minimize percutaneous absorption and neurotoxicity risk

Indications

Eradication of pediculosis capitis (head lice)
Treatment of scabies and other ectoparasite infestations where resistance has not rendered it obsolete

Mechanism of Action

Clofenotane (DDT) acts on the nerve cell membranes of arthropods, keeping sodium channels open and causing repeated nerve discharges, leading to paralysis and death
Combination agents (e.g., benzyl benzoate, benzocaine) provide synergistic parasiticidal and local anesthetic effects

Contraindications

Known hypersensitivity to clofenotane or any formulation excipients
Application to inflamed, broken, or raw skin surfaces
Use near eyes, mucous membranes, or urethral meatus

Adverse Reactions

Local skin irritation, erythema, burning, or stinging at the application site
Contact dermatitis and allergic skin reactions
Potential central nervous system toxicity (tremors, dizziness) if absorbed systemically in large amounts

Drug Interactions

Concurrent use of other topical neurotoxic insecticides should be avoided to prevent additive toxicity
Lipophilic excipients or oils may enhance the percutaneous absorption of clofenotane, increasing systemic risk

Curated Content: Needs Vetting Before Put to Clinical Use