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ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS › ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS › ECTOPARASITICIDES, INCL. SCABICIDES › Other ectoparasiticides, incl. scabicides
abametapir
P03AX07
Forms & Strengths
- Topical lotion: 0.74% (7.4 mg/mL)
Adult Dosing
- Pediculosis capitis: Apply sufficient lotion to dry hair and scalp to thoroughly coat hair and scalp, leave on for 10 minutes, then rinse thoroughly with warm water.
- Limit application to a single treatment.
Pediatric Dosing
- Pediculosis capitis (Patients 6 months of age and older): Apply sufficient lotion to dry hair and scalp to thoroughly coat hair and scalp, leave on for 10 minutes, then rinse thoroughly with warm water.
- Limit application to a single treatment.
Indications
- Treatment of head lice infestation in patients 6 months of age and older
Mechanism of Action
- Metalloenzyme inhibitor that inhibits cytochrome P450 (CYP) enzymes, leading to disruption of physiological processes essential for the survival and development of lice.
Adverse Reactions
- Erythema of the skin
- Rash
- Skin burning sensation
- Contact dermatitis
- Eye irritation
- Nausea
Drug Interactions
- May inhibit CYP1A2, CYP2B6, and CYP3A4 enzymes, potentially increasing systemic exposure of co-administered substrates of these enzymes.
- Avoid concomitant use of sensitive CYP substrates with narrow therapeutic index where applicable, though systemic absorption is minimal.
Curated Content: Needs Vetting Before Put to Clinical Use