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ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS › ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS › INSECTICIDES AND REPELLENTS › Pyrethrines
cyfluthrin
P03BA01
Forms & Strengths
- Emulsifiable concentrate (various concentrations, e.g., 2% to 20%)
- Wettable powder
- Liquid pour-on or spray formulations for veterinary/agricultural use
Adult Dosing
- Not approved for direct systemic use in humans
- Topical exposure: Wash contaminated skin thoroughly with soap and water
- Ocular exposure: Flush eyes with copious amounts of water for at least 15 minutes
- Inhalation/Ingestion: Remove from exposure source and provide symptomatic supportive care
Pediatric Dosing
- No approved therapeutic use in children
- Management of accidental exposure follows adult supportive care guidelines based on body weight
Indications
- Agricultural and structural ectoparasite and pest control (synthetic pyrethroid insecticide)
- Veterinary applications for livestock pest management
Mechanism of Action
- Type II synthetic pyrethroid
- Interferes with sodium ion channel gating in the insect nervous system
- Causes prolonged sodium channel activation, resulting in repetitive nerve discharges, paralysis, and death in arthropods
Contraindications
- Direct application to humans or human food products unless specifically formulated and approved
- Known hypersensitivity to cyfluthrin or other pyrethroid insecticides
Adverse Reactions
- Paresthesia, burning, or stinging sensation on skin contact (temporary facial paresthesia)
- Dizziness, headache, nausea, and vomiting upon significant exposure
- Respiratory irritation, coughing, and shortness of breath upon inhalation
- Seizures, muscle fasciculations, and pulmonary edema in severe poisoning cases
Drug Interactions
- Synergistic toxicity with organophosphate insecticides due to inhibited metabolism
- Potential potentiation of neurotoxic effects when combined with other neurotoxic agents
Curated Content: Needs Vetting Before Put to Clinical Use