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ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS › ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS › INSECTICIDES AND REPELLENTS › Pyrethrines
decamethrin
P03BA03
Forms & Strengths
- Topical shampoo 0.02%
- Topical suspension 0.005%
- Veterinary ectoparasiticide formulations
Adult Dosing
- Pediculosis capitis: Apply topical preparation to affected area, leave for specified duration (typically 10 minutes), and rinse thoroughly.
- Scabies: Apply topically as directed, single application usually sufficient, repeat if live mites observed after 7-10 days.
Pediatric Dosing
- Pediatric safety and efficacy established for children >2 years for approved topical ectoparasite indications.
- Apply topical formulation to affected area, avoiding eyes and mucous membranes, rinse after prescribed duration.
Indications
- Treatment of pediculosis capitis (head lice)
- Treatment of Sarcoptes scabiei (scabies)
- Control of ectoparasite infestations in veterinary medicine
Mechanism of Action
- Type II pyrethroid insecticide that acts on the voltage-gated sodium channels of nerve cell membranes.
- Delays channel inactivation, leading to repetitive nerve discharges, paralysis, and death of the parasite.
Contraindications
- Hypersensitivity to decamethrin, other pyrethroids, or any component of the formulation
- Application to broken skin, inflamed skin, or near the eyes and mucous membranes
Adverse Reactions
- Local skin irritation, burning, or stinging at application site
- Erythema and pruritus
- Transient paresthesia (rare with topical use)
- Contact dermatitis
Drug Interactions
- Concomitant topical corticosteroids may mask signs of pyrethroid-induced skin irritation
- Potential synergistic toxicity with other neurotoxic insecticides
- Minimal systemic absorption limits significant systemic drug-drug interactions
Curated Content: Needs Vetting Before Put to Clinical Use