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RESPIRATORY SYSTEM › NASAL PREPARATIONS › DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE › Sympathomimetics, plain
naphazoline
R01AA08
Forms & Strengths
- Ophthalmic solution: 0.1%
Adult Dosing
- Ophthalmic: Instill 1 to 2 drops in the affected eye(s) every 3 to 4 hours as needed.
Pediatric Dosing
- Children < 6 years: Safety and efficacy not established.
- Children >= 6 years: Instill 1 to 2 drops in the affected eye(s) every 3 to 4 hours as needed.
Indications
- Relief of redness of the eyes due to minor eye irritations
Mechanism of Action
- Direct-acting alpha-adrenergic agonist that stimulates alpha receptors on vascular smooth muscle in conjunctiva, producing vasoconstriction and reducing ocular hyperemia.
Contraindications
- Hypersensitivity to naphazoline or any component of the formulation
- Patients with narrow-angle glaucoma
Adverse Reactions
- Transient stinging or burning upon instillation
- Mydriasis
- Increased intraocular pressure
- Rebound hyperemia (with prolonged use)
- Systemic effects (hypertension, headache, cardiac irregularities in rare cases of excessive absorption)
Drug Interactions
- Monoamine oxidase inhibitors (MAOIs): Concurrent use may precipitate a severe hypertensive crisis
- Central nervous system depressants: May enhance CNS depression when systemically absorbed
Curated Content: Needs Vetting Before Put to Clinical Use