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RESPIRATORY SYSTEM › NASAL PREPARATIONS › DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE › Sympathomimetics, plain
tymazoline
R01AA13
Forms & Strengths
- 0.05% nasal spray
- 0.1% nasal spray
Adult Dosing
- 2-3 sprays per nostril, 2-3 times a day
- Maximum dose: 12 sprays in 24 hours
Pediatric Dosing
- 6-12 years: 1-2 sprays per nostril, 2-3 times a day
- Under 6 years: Not recommended
Indications
- Relief of nasal congestion
- Perennial allergic rhinitis
- Vasomotor rhinitis
Mechanism of Action
- Selective alpha-2 adrenergic agonist
- Reduces nasal blood flow and swelling
Contraindications
- Hypersensitivity to tymazoline
- Children under 6 years old
Adverse Reactions
- Dryness of nasal mucosa
- Burning sensation
- Sneezing
- Nasal irritation
Drug Interactions
- MAOIs: increased risk of hypertensive crisis
- Tricyclic antidepressants: increased risk of hypertensive crisis
Curated Content: Needs Vetting Before Put to Clinical Use