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RESPIRATORY SYSTEM › NASAL PREPARATIONS › DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE › Antiallergic agents, excl. corticosteroids
antazoline
R01AC04
Forms & Strengths
- Nasal spray 0.2% solution (≈0.2 mg/actuation)
- Ophthalmic solution 0.1% (1 mg/mL)
Adult Dosing
- Nasal spray: 1‑2 sprays/nostril 3‑4 times daily (max 8 sprays/day)
- Ophthalmic drops: 1‑2 drops/eye 3‑4 times daily
Pediatric Dosing
- Children ≥2 yr: nasal spray 1 spray/nostril 3‑4 times daily
- Children ≥2 yr: ophthalmic drops 1 drop/eye 2‑3 times daily
- Not recommended for children <2 yr
Indications
- Allergic rhinitis
- Vasomotor rhinitis
- Nasal congestion due to allergy
- Allergic conjunctivitis
- Seasonal allergic eye symptoms
Mechanism of Action
- Competitive H1‑histamine receptor antagonist
- Anticholinergic (muscarinic) blockade
- Reduces vascular permeability and secretions
- Provides symptomatic relief of nasal and ocular allergy
Contraindications
- Hypersensitivity to antazoline or excipients
- Narrow‑angle glaucoma
- Severe prostatic hypertrophy/urinary retention
- Use in pregnancy only if benefit outweighs risk
Adverse Reactions
- Drowsiness
- Dry mouth
- Nasal irritation or burning
- Blurred vision
- Headache
- Tachycardia
- Urinary retention
- Palpitations
Drug Interactions
- Additive CNS depression with alcohol, benzodiazepines, other antihistamines
- Increased anticholinergic load with tricyclic antidepressants, antipsychotics, antiparkinson agents
- Concurrent topical decongestants may increase risk of rebound congestion
- Caution with beta‑blockers (possible tachycardia)
Curated Content: Needs Vetting Before Put to Clinical Use