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RESPIRATORY SYSTEM › NASAL PREPARATIONS › DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE › Antiallergic agents, excl. corticosteroids
olopatadine
R01AC08
Forms & Strengths
- Ophthalmic solution: 0.1% (5 mL), 0.2% (2.5 mL), 0.7% (2.5 mL)
- Nasal spray: 0.6% (665 mcg per spray, 30.5 g bottle)
Adult Dosing
- Allergic conjunctivitis (0.1%): 1 drop in affected eye(s) twice daily (approx. 6-8 hours apart)
- Allergic conjunctivitis (0.2%): 1 drop in affected eye(s) once daily
- Allergic conjunctivitis (0.7%): 1 drop in affected eye(s) once daily
- Allergic rhinitis: 2 sprays per nostril twice daily
Pediatric Dosing
- Allergic conjunctivitis (Children >= 2 years): 1 drop in affected eye(s) twice daily (0.1%) or once daily (0.2% or 0.7%)
- Allergic rhinitis (Children 6 to 11 years): 1 spray per nostril twice daily
- Allergic rhinitis (Adolescents >= 12 years): 2 sprays per nostril twice daily
Indications
- Treatment of signs and symptoms of allergic conjunctivitis
- Relief of the symptoms of seasonal allergic rhinitis
Mechanism of Action
- Selective histamine H1-receptor antagonist
- Inhibits the release of histamine from mast cells
- Prevents histamine-induced inflammatory mediator release from conjunctival epithelial cells
Contraindications
- Hypersensitivity to olopatadine or any component of the formulation
Adverse Reactions
- Headache
- Bitter taste (dysgeusia)
- Epistaxis
- Nasal discomfort or burning
- Eye irritation, stinging, or dry eyes
- Somnolence
Drug Interactions
- No clinically significant pharmacokinetic drug interactions reported
- Concurrent use with other CNS depressants may theoretically potentiate drowsiness when using the nasal spray
Curated Content: Needs Vetting Before Put to Clinical Use